KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDH1B
All Species:
14.85
Human Site:
S189
Identified Species:
27.22
UniProt:
Q5I0G3
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5I0G3
NP_001034934.1
518
58651
S189
V
E
T
Q
D
L
A
S
P
V
L
R
S
V
S
Chimpanzee
Pan troglodytes
XP_001138429
518
58619
S189
V
E
T
Q
D
L
A
S
P
V
L
R
S
V
S
Rhesus Macaque
Macaca mulatta
XP_001106735
518
58711
S189
M
E
T
Q
D
L
A
S
P
V
L
R
S
V
S
Dog
Lupus familis
XP_536042
532
60173
A189
A
E
T
Q
D
L
V
A
P
L
L
Q
S
I
S
Cat
Felis silvestris
Mouse
Mus musculus
Q5F204
500
56279
S189
M
E
T
Q
D
L
A
S
P
V
L
R
T
V
S
Rat
Rattus norvegicus
O88989
334
36465
S28
L
Y
S
I
G
N
G
S
V
F
G
K
D
Q
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508036
548
61874
A181
I
A
A
Q
D
L
A
A
P
L
L
R
N
I
S
Chicken
Gallus gallus
Q5ZME2
334
36525
D28
L
Y
S
I
A
K
G
D
V
F
G
K
E
Q
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q08BZ4
447
50254
N141
I
W
I
S
S
A
L
N
P
V
C
Y
S
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_394487
333
36140
A26
S
L
L
Y
Q
L
A
A
G
T
V
F
G
P
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001201789
553
61629
C183
M
E
V
F
D
L
A
C
P
L
L
R
G
V
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08062
332
35571
A26
Y
A
L
V
P
M
I
A
R
G
V
M
L
G
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P93819
332
35552
A26
Y
A
L
V
P
M
I
A
R
G
I
M
L
G
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.4
95.9
77.2
N.A.
69.1
20.6
N.A.
55.8
20.2
N.A.
39.9
N.A.
N.A.
20.2
N.A.
36.8
Protein Similarity:
100
99.6
97.4
87.9
N.A.
82.8
35.5
N.A.
72.4
33.9
N.A.
58.4
N.A.
N.A.
38.4
N.A.
55.1
P-Site Identity:
100
100
93.3
60
N.A.
86.6
6.6
N.A.
53.3
0
N.A.
20
N.A.
N.A.
13.3
N.A.
53.3
P-Site Similarity:
100
100
100
86.6
N.A.
100
26.6
N.A.
86.6
20
N.A.
40
N.A.
N.A.
33.3
N.A.
66.6
Percent
Protein Identity:
N.A.
21.8
N.A.
21.2
N.A.
N.A.
Protein Similarity:
N.A.
35.7
N.A.
35.9
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
24
8
0
8
8
54
39
0
0
0
0
0
0
16
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% C
% Asp:
0
0
0
0
54
0
0
8
0
0
0
0
8
0
0
% D
% Glu:
0
47
0
0
0
0
0
0
0
0
0
0
8
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
16
0
8
0
0
0
% F
% Gly:
0
0
0
0
8
0
16
0
8
16
16
0
16
16
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
16
0
8
16
0
0
16
0
0
0
8
0
0
16
8
% I
% Lys:
0
0
0
0
0
8
0
0
0
0
0
16
0
0
8
% K
% Leu:
16
8
24
0
0
62
8
0
0
24
54
0
16
8
0
% L
% Met:
24
0
0
0
0
16
0
0
0
0
0
16
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
8
0
0
0
0
8
0
8
% N
% Pro:
0
0
0
0
16
0
0
0
62
0
0
0
0
8
16
% P
% Gln:
0
0
0
47
8
0
0
0
0
0
0
8
0
16
0
% Q
% Arg:
0
0
0
0
0
0
0
0
16
0
0
47
0
0
0
% R
% Ser:
8
0
16
8
8
0
0
39
0
0
0
0
39
0
47
% S
% Thr:
0
0
39
0
0
0
0
0
0
8
0
0
8
0
0
% T
% Val:
16
0
8
16
0
0
8
0
16
39
16
0
0
39
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
16
0
8
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _